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Design study of dedicated brain PET with polyhedron geometry

Issue title: Papers from the 3rd International Conference on Biomedical Engineering and Technology (iCBEB 2014), 25–28 September 2014, Beijing, China

Subtitle:

Guest editors: Edward J. Ciaccio

Article type: Research Article

Authors: Shi, Hana; d | Du, Donga | Xu, JianFengb | Su, Zhihongc | Peng, Qiyud; *

Affiliations: [a] Tsinghua University, Beijing, China | [b] Huazhong University of Science and Technology, Wuhan, Hubei, China | [c] Southern Medical University, Guangzhou, Guangdong, China | [d] Lawrence Berkeley National Laboratory, Berkeley, CA, USA

Correspondence: [*] Corresponding author: Qiyu Peng, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. E-mail:qpeng@lbl.gov

Keywords: Positron emission tomography (PET), brain imaging, polyhedron geometry

DOI: 10.3233/THC-151000

Journal: Technology and Health Care, vol. 23, no. s2, pp. S615-S623, 2015

Published: 2015
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Abstract

BACKGROUND: Despite being the conventional choice, whole body PET cameras with a 76 cm diameter ring are not the optimal means of human brain imaging.

OBJECTIVE: In fact, a dedicated brain PET with a better geometrical structure has the potential to achieve a higher sensitivity, a higher signal-to-noise ratio, and a better imaging performance.

METHODS: In this study, a polyhedron geometrical dedicated brain PET (a dodecahedron design) is compared to three other candidates via their geometrical efficiencies by calculating the Solid Angle Fractions (SAF); the three other candidates include a spherical cap design, a cylindrical design, and the conventional whole body PET.

RESULTS: The spherical cap and the dodecahedron have an identical SAF that is 58.4% higher than that of a 30 cm diameter cylinder and 5.44 times higher than that of a 76 cm diameter cylinder. The conceptual polygon-shape detectors (including pentagon and hexagon detectors based on the PMT-light-sharing scheme instead of the conventional square-shaped block detector module) are presented for the polyhedron PET design. Monte Carlo simulations are performed in order to validate the detector decoding.

CONCLUSIONS: The results show that crystals in a pentagon-shape detector can be successfully decoded by Anger Logic. The new detector designs support the polyhedron PET investigation.

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