NMR spectroscopic study of inclusion complexes of cetirizine dihydrochloride and β-cyclodextrin in solution

Article type: Research Article

Authors: Ali, Syed Mashhood | Upadhyay, Santosh Kumar | Maheshwari, Arti

Affiliations: Department of Chemistry, Aligarh Muslim University, Aligarh-202 002 (UP), India

Note: [] Corresponding author. E-mail: smashhoodali@yahoo.com

Abstract: Cetirizine dihydrochloride (CTZ), an antihistamine, forms two 1:1 inclusion complexes with β-cyclodextrin (β-CD) in aqueous solution as confirmed by detailed 1H NMR, COSY and ROESY spectroscopic studies. The stoichiometry and overall binding constant of the complexes were determined by the treatment of 1H NMR chemical shift change (Δδ) data. Most of the CTZ protons exhibited splitting in the presence of β-CD.

Keywords: Cetirizine dihydrochloride, β-cyclodextrin, inclusion complex, NMR spectroscopy, ROESY, COSY

Journal: Spectroscopy, vol. 21, no. 3, pp. 177-182, 2007