Affiliations: [a] Department of Biochemistry, Pt. B.D. Sharma PGIMS, Rohtak 124001, Haryana, India | [b] H. No. 1447, Sector-I, Rohtak 124001, Haryana, India. e-mail: simmikh@rediffmail.com
| [c] Department of Obstetrics and Gynecology, Pt. B.D. Sharma PGIMS, Rohtak 124001, Haryana, India
Abstract: The present study was designed to analyze cord blood atherogenic index (AI) in newborns of normal pregnant and preeclamptic subjects and to correlate them with birth weight and maternal AI. The study consisted of 50 healthy pregnant women (Group I: controls) and 50 women with preeclampsia. Ten milliliter cord blood was collected from placental end of umbilical cord and 5 ml of maternal venous sample was drawn from antecubital vein at the time of delivery. Serum was separated by centrifugation and Apo A-I and Apo B levels were analyzed by immunoturbidimetric Immunoassay kits. AI was calculated as ratio of Apo B to Apo A-I. Apo B levels were significantly elevated in Group II in both cord blood and maternal blood as compared to Group I (p < 0.001). Apo A-I levels were lower in maternal blood and higher in cord blood of group II. In maternal blood, AI was higher in Group II as compared to Group I (p < 0.001). In group I, a significant positive correlation was observed between cord blood AI and birth weight and values being higher in males. In group II, a significant negative correlation observed between cord blood AI and birth weight was higher in females.
