Affiliations: [a] Nutrition Department, Faculty of Nursing and Health Science, Universitas Muhammadiyah Semarang, Semarang, Indonesia
| [b] Programme in Medical Education, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia
| [c] Fish Product Technology, Faculty of Fisheries and Marine Science, Universitas Diponegoro, Semarang, Indonesia
Correspondence:
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Corresponding author: Luthfia Dewi, Nutrition Department, Faculty of Nursing and Health Science, Universitas Muhammadiyah Semarang, Semarang, Indonesia. Tel.: +62 24 76740296; Fax: 024 76740291; E-mail: luthfia@unimus.ac.id.
Abstract: BACKGROUND:Cardiovascular disease (CVD) appears to be the fundamental cause of morbidity and mortality in type 2 diabetes mellitus (T2DM). Improving the level of lipoprotein ratios using natural ingredients was widely used. OBJECTIVE:This study aimed to examine antioxidant source-Litopenaeus vannamei shell powder (LVSP) to rebalance the lipoprotein ratios in diabetic rats. METHODS:A-14 days prior to streptozotocin (STZ) injection, male Wistar rats (n = 30) were evenly grouped into non-intervention (C–), pre-intervention high-fat diet (C+), pre-intervention high-fat diet with LVSP dose 0.89 g/body weight (BW), pre-intervention high-fat diet with LVSP dose 1.77 g/BW (T2), and pre-intervention high-fat diet with astaxanthin 0.09 mg/BW (T3). RESULTS:A reduction of LDL, total cholesterol (TC), and TC/HDL, LDL/HDL, and LDL/TC ratio was observed (p < 0.001). A negative, strong correlation was found between the change of adiponectin to the change of TC (r=–0.94), LDL (r=–0.92), TC/HDL (r=–0.94), LDL/HDL (r=–0.91), and LDL/TC (r=–0.82). The magnitude of improvement showed a dose-dependent manner, and the high dose delineated a comparable effect to astaxanthin. CONCLUSION:The present study brought a profound finding on the potential of LV to reduce cardiovascular index in T2DM rats.
Keywords: Antioxidant, diabetes, lipid, lipoprotein ratio
