Affiliations:
Department of Radiology, The First Hospital of Jiaxing or The Affiliated Hospital of Jiaxing University, Jiaxing, China
Correspondence:
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Corresponding author: Jun Han, MD, Department of Radiology, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, Jiaxing, China. Tel.: +86 13706735435; Email: 13706735435@163.com.
Abstract: BACKGROUND:The main metastatic route for lung cancer is lymph node metastasis, and studies have shown that non-small cell lung cancer (NSCLC) has a high risk of lymph node infiltration. OBJECTIVE:This study aimed to compare the performance of handcrafted radiomics (HR) features and deep transfer learning (DTL) features in Computed Tomography (CT) of intratumoral and peritumoral regions in predicting the metastatic status of NSCLC lymph nodes in different machine learning classifier models. METHODS:We retrospectively collected data of 199 patients with pathologically confirmed NSCLC. All patients were divided into training (n = 159) and validation (n = 40) cohorts, respectively. The best HR and DTL features in the intratumoral and peritumoral regions were extracted and selected, respectively. Support Vector Machine (SVM), k-Nearest Neighbors (KNN), Light Gradient Boosting Machine (Light GBM), Multilayer Perceptron (MLP), and Logistic Regression (LR) models were constructed, and the performance of the models was evaluated. RESULTS:Among the five models in the training and validation cohorts, the LR classifier model performed best in terms of HR and DTL features. The AUCs of the training cohort were 0.841 (95% CI: 0.776–0.907) and 0.955 (95% CI: 0.926–0.983), and the AUCs of the validation cohort were 0.812 (95% CI: 0.677–0.948) and 0.893 (95% CI: 0.795–0.991), respectively. The DTL signature was superior to the handcrafted radiomics signature. CONCLUSIONS:Compared with the radiomics signature, the DTL signature constructed based on intratumoral and peritumoral areas in CT can better predict NSCLC lymph node metastasis.
