Affiliations: [a] Department of Radiology, Henan Provincial People’s Hospital and Zhengzhou University People’s Hospital, Zhengzhou, Henan, China
| [b] Department of Radiology, The first Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China
| [c] Department of Hematology, Henan Provincial People’s Hospital & Hemophilia Diagnosis and Treatment Center of Henan Province, Henan, China
Correspondence:
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Corresponding author: Yinghui Ge, Department of Radiology, Henan Provincial People’s Hospital and Zhengzhou University People’s Hospital, Zhengzhou, Henan 450003, China. E-mail: cjr.geyinghui@vip.163.com.
Abstract: OBJECTIVE:To evaluate the potential of synovial membrane volume measurement by MRI in monitoring the effect of radiation synovectomy on patients of Hemophilic Arthropathy (HA). METHODS:We studied 63 diseased joints of 42 HA patients who received hospitalized services at the Hemophilia Diagnosis and Treatment Center of Henan Provincial People’s Hospital from May 2011 to January 2015. Unenhanced and enhanced MR scanning of each diseased joint was performed simultaneously. The volumes of synovial membrane of 21 joints from 16 patients before and after being treated with 32P radiation synovectomy (PRS) were measured and compared using image post-processing software and workstation. Two sample matching t test was conducted to analyze the synovial membrane volumes of the same joint measured by unenhanced and enhanced MR, as well as change of MR enhancement ratio after treatments. RESULTS:The synovial membrane volumes measured by unenhanced versus enhanced MR scanning showed no statistical significance. Significant reduction (t = 7.831, p < 0.001) of the synovial membrane volume after treatment (2479.45±46.48 mm3 versus 2983.30±42.87 mm3 before treatment) was observed. MR enhancement ratio of synovial membrane decreased after treatment (0.92±0.06 after vs 1.17±0.07 before treatment) with statistical significance. CONCLUSION:The synovial membrane volume and MR enhancement ratio can be used to monitor patient response to PRS treatment.
Keywords: Hemophilia, osteoarthropathy, secondary hypertrophic, clinical efficacy, magnetic resonance imaging
