Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Chen, Po-Choua | Shoa, Kuan-Hsiungb | Jao, Jo-Chic; * | Hsiao, Chia-Chid
Affiliations: [a] Department of Biomedical Engineering, I-Shou University, Kaohsiung City, Taiwan, ROC | [b] Department of Radiology, Jhong Jheng Orthopedic Hospital, Kaohsiung City, Taiwan, ROC | [c] Department of Medical Imaging and Radiological Sciences, College of Health Sciences, Kaohsiung Medical University, Kaohsiung City, Taiwan, ROC | [d] Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan, ROC
Correspondence: [*] Corresponding author: Jo-Chi Jao, Ph.D. address: (80708) No.100, Shih-Chuan 1st Rd., Kaohsiung, Taiwan, ROC. Tel.: +886 7 3121101 / Ext. 2356-14; Fax: +886 7 3113449; E-mail: jochja@kmu.edu.tw.
Abstract: BACKGROUND:Anesthesia may alter the cellular components contributing to the magnetic resonance imaging (MRI) signal intensities. Developing awake animal models to evaluate cerebral function has grown in importance. OBJECTIVE: To investigate a noninvasive strategy for dynamic MRI (dMRI) of awake rabbits during carbogen challenge. METHODS: A nonmetallic assistive device with a self-adhering wrap secure procedure was developed for the head fixation of awake rabbits. Multi-shot gradient echo echo-planar imaging sequence was applied for the dMRI on a 1.5 T clinical MRI scanner with a quadrature head coil. The carbogen challenge pattern was applied in a sequence of air - carbogen - air - carbogen - air. Twelve scans were performed for each block of carbogen challenge. T2-weighted fast-spin echo and T1-weighted gradient echo sequences were performed before and after dMRI to evaluate the head position shifts. The whole dMRI scan time was about 30 minutes. RESULTS:The position shift of 8 rabbits in the x-and y-direction was less than 3%. The average MRI signal intensities (SI) from the 8 rabbits during carbogen challenge was fitted well using exponential growth and decay functions. The average MRI SI increase due to carbogen inhaling was 1.51%. CONCLUSIONS: The proposed strategy for head dMRI on an awake rabbit during carbogen challenge is feasible.
Keywords: Rabbit brain, awake, assistive device, self-adhering wrap, fixation, magnetic resonance imaging
DOI: 10.3233/XST-180395
Journal: Journal of X-Ray Science and Technology, vol. 26, no. 6, pp. 997-1009, 2018
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl