Affiliations: College of Precision Instruments and Optoelectronics
Engineering, Tianjin University, Tianjin, China | Tianjin Key Laboratory of Biomedical Detecting
Techniques and Instruments, Tianjin, China
Note: [] Corresponding author: Huijuan Zhao, College of Precision
Instruments and Optoelectronics Engineering, Tianjin University, Tianjin
300072, China. E-mail: huijuanzhao@tju.edu.cn. Tel.: +86 022 27404209; E-mail:
huijuanzhao@tju.edu.cn
Abstract: A near infrared diffuse reflectance system for endoscopic
measurement and an inverse algorithm for extracting optical properties of
tubular tissues were developed in this paper. The measurement system worked in
the frequency domain mode and a custom probe was employed for endoscopic
detection of cervical cancer. Experiments for evaluating the measurement
accuracy indicate that the model-to-data mismatch for the AC amplitude and
phase lag is less than 3.7% and 6.7%, respectively. To facilitate the
extraction of the optical properties in tubular tissues and to minimize the
influence of the initial guess on the reconstruction accuracy, a fast inverse
Monte Carlo simulation algorithm with cluster analysis method was proposed.
Simulation results showed that the relative errors of the absorption
coefficient recovered using the proposed inverse algorithm are less than
5.8% and those of the sacttering coefficient are less than 10.2%.
Endoscopic measurement on two tubular solid phantoms were also carried out to
evaluate the system and the inversion scheme. The results demonstrated that
less than 20% relative error can be achieved.
Keywords: Near-infrared diffuse reflectance, frequency domain, inverse monte carlo simulation, endoscopic measurement
