Affiliations: Carman and Ann Adams Department of Pediatrics, Wayne
State University, School of Medicine, Detroit, MI, USA
Note: [] Correspondence: Graham C. Parker, PhD, Children's Hospital of
Michigan, 3901 Beaubien, Detroit, MI 48201, USA. Tel.: +1 313 745 2400; Fax: +1
313 745 0282; E-mail: gparker@med.wayne.edu
Abstract: Cerebral stroke can cause permanent neurological damage, behavioral
incapacity and is associated with a high personal and financial cost.
Therapeutic options are severely limited. In the past 10 years there has been
an explosion of research interest in how a variety of stem cell populations
respond in animal models of stroke. Manipulation of endogenous and exogenously
introduced stem cells has provided a preponderance of information on how stem
cells may improve aspects of cellular and functional recovery following largely
ischemic models of stroke. These in turn have led the way to the initiation of
clinical trials.
