Affiliations: Department of Obstetrics Gynecology and Child Health,
University of the West Indies, Kingston, Jamaica | Department of Surgery, Anesthesia, Intensive Care and
Radiology, University of the West Indies, Kingston, Jamaica
Note: [] Correspondence: Dr. Roxanne H. Melbourne Chambers, Department
of Obstetrics Gynecology and Child Health, University of the West Indies,
Kingston, Jamaica. Tel.: +1 876 970 0329; Fax: +1 876 927 1446; E-mail:
roxhmc@yahoo.com
Abstract: Two male infants who were both survivors of monochorionic twin
pregnancies in which there was intrauterine demise of one twin are described.
These infants had features of microcephaly associated with radiologic features
of porencephaly, hydranencephaly and microcranium. The diagnosis assigned was
severe fetal brain disruption sequence. Both infants had severe developmental
delay and one infant died suddenly at age 7 months. A comparison is made with
previously reported cases. The diagnosis of fetal brain disruption sequence
should be entertained in infants with severe congenital microcephaly with
overlapping sutures associated with scalp rugae and should be anticipated in
twin pregnancies in which there has been demise of one co-twin during the
second trimester.
