Affiliations: Department of Pediatrics, Louisiana State University
Health Sciences Center, Shreveport, LA, USA | Department of Radiology, Louisiana State University
Health Sciences Center, Shreveport, LA, USA
Note: [] Correspondence: Olugbenga A. Akingbola, MD, Department of
Pediatrics, 1501 Kings Hwy., P. O. Box 33932, Shreveport, LA 71130-3932, USA.
Tel.: +1 504 988 5601; Fax: +1 504 988 7660; E-mail: gbenggo@yahoo.com
Abstract: This is a case of posterior leukoencephalopathy syndrome (PLES) in
an 11-year-old African-American male treated with oral cyclosporine while on
admission for idiopathic aplastic anemia in the intensive care unit at
Louisiana State University, Shreveport, USA. The patient had tonic-clonic
seizures preceded by visual hallucinations and hypertension. Magnetic resonance
imaging with fluid attenuated inversion-recovery sequences revealed presence of
cerebral edema in the cortical and subcortical regions of the frontal,
supraventricular and posterior parietal lobes consistent with PLES. Resolution
of PLES lesions occurred with a 25% reduction in dose of oral cyclosporine,
control of seizure activity and treatment of hypertension. Patient recovered
completely and was discharged home on anticonvulsant and antihypertensive
medications that were subsequently discontinued at follow-up visit.
