Affiliations: Pediatric Infectious Diseases Section, Children
Hospital, King Fahad Medical City, Riyadh, Saudi Arabia
Note: [] Corresponding author: May Al Barrak, Pediatric Infectious
Diseases Section, Children Hospital, King Fahad Medical City, P.O. Box 59046,
Riyadh 11525, Kingdom of Saudi Arabia. Tel.: +966 1 288 9999 ext. 2652; Fax:
+966 1 288 9999 ext. 2205; E-mail: may-albarrak@hotmail.com
Abstract: Hemorrhagic cystitis is often a serious condition in cancer patients
and can be life threatening despite aggressive treatment measures. The
condition may be secondary to infections, radiation or chemotherapy.
Oxazaphosphorine alkylating agents, such as cyclophosphamide and ifosfamide,
are the most frequent causes of chemotherapy-induced HC in cancer patients.
Only a few cases of BK virus-associated hemorrhagic cystitis in non-transplant
cancer patients have been reported worldwide. Here, we report two cases of
BK-induced HC in non-transplant oncology patients; one patient died due to
multi-system failure of unknown etiology, and the other patient was treated
successfully with low-dose cidofovir.
Keywords: BK virus, hemorrhagic cystitis, non-transplant, low-dose cidofovir
