Affiliations: Department of Pediatrics, Division of Infectious
Diseases, Duke Children's Hospital, Durham, NC, USA | Department of Pediatrics, Division of Infectious
Diseases, Kaiser Permanente Medical Center, Lancaster, CA, USA | Department of Pediatrics, Division of Infectious
Diseases, California Pacific Medical Center, San Francisco, CA, USA | Department of Biostatistics, David Geffen School of
Medicine at UCLA, Los Angeles, CA, USA | Department of Pediatrics, Division of Infectious
Diseases, Mattel Children's Hospital at UCLA, Los Angeles, CA, USA
Note: [] Correspondence: Ravi Jhaveri, M.D., Division of Infectious
Diseases, Duke Children's Hospital, Box 3499, Durham, NC 27710-0001, USA. Tel.:
+1 919 684 6335; Fax: +1 919 668 4859; E-mail: ravi.jhaveri@duke.edu
Abstract: Infections with organisms producing extended-spectrum
beta-lactamases are associated with well established risk factors and poor
outcomes in adults, but these are less well defined in children. Our
case-control analysis showed that infections with extended-spectrum
beta-lactamases producing organisms are linked to prolonged antibiotic usage
and are possibly associated with prolonged length of stay and worse overall
outcomes in hospitalized children. Efforts to limit the duration and narrow the
spectrum of antimicrobial therapy may assist in controlling infections due to
these organisms.
Keywords: ESBL, extended-spectrum beta-lactamases, antimicrobials, E. coli, K. pneumoniae, children, pediatrics
