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Article type: Research Article
Authors: Campese, Nicole | Leys, Fabian | Wenning, Gregor K. | Fanciulli, Alessandra; *
Affiliations: Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria
Correspondence: [*] Correspondence to: Alessandra Fanciulli, MD, PhD, Department of Neurology, Medical University of Innsbruck, Anichstraße 35, A-6020 Innsbruck, Austria. Tel.: +43 512 504 83238; E-mail: alessandra.fanciulli@i-med.ac.at.
Abstract: Multiple system atrophy (MSA) is a rare, rapidly progressive neurodegenerative disorder of the adulthood, characterized by autonomic failure, parkinsonian and cerebellar features in various combinations. Distinguishing MSA from common clinical look-alikes such as Parkinson's disease, other atypical parkinsonian disorders or alternative causes of sporadic adult-onset cerebellar ataxia may be difficult, especially at early disease stages. Nonetheless, some simple and cost-effective screening tools help detecting important red flags guiding towards a MSA diagnosis. Here we outline which clinical pearls and bedside tests may disclose autonomic dysfunction in multiple domains, enabling an early MSA diagnosis and, even more importantly, personalized treatment.
Keywords: Dysautonomia, multiple system atrophy, neurogenic bladder, orthostatic hypotension, parkinsonian disorders, vasomotor control
DOI: 10.3233/JPD-223357
Journal: Journal of Parkinson's Disease, vol. 12, no. 7, pp. 2277-2281, 2022
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