Subcortical Iron Accumulation Pattern May Predict Neuropsychological Outcomes After Subthalamic Nucleus Deep Brain Stimulation: A Pilot Study

Article type: Research Article

Authors: Brown, Gregory^a | Du, Guangwei^{a; f} | Farace, Elana^{b; c} | Lewis, Mechelle M.^{a; d} | Eslinger, Paul J.^a | McInerney, James^b | Kong, Lan^c | Li, Runze^g | Huang, Xuemei^{a; b; d; e; f; g} | De Jesus, Sol^{a; *}

Affiliations: [a] Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA | [b] Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA | [c] Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA | [d] Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA | [e] Department of Statistics, Pennsylvania State University, University Park, PA, USA | [f] Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA | [g] Department of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA

Correspondence: [*] Correspondence to: Sol De Jesus, MD, Department of Neurology, Penn State-Hershey Medical Center, Hershey, PA 17033, USA. Tel.: +1 717 531 0003/ Ext.: 287082; E-mail: sdejesus@pennstatehealth.psu.edu.

Keywords: Parkinson’s disease, deep brain stimulation, MRI, R2^*, neuropsychiatric outcomes

DOI: 10.3233/JPD-212833

Journal: Journal of Parkinson's Disease, vol. 12, no. 3, pp. 851-863, 2022