Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Letzkus, L.a; * | Conaway, M.b | Daugherty, R.c | Hook, M.c | Zanelli, S.d
Affiliations: [a] Department of Pediatrics, Division of Developmental Pediatrics, University of Virginia, Charlottesville, VA, USA | [b] Public Health Sciences, University of Virginia, Charlottesville VA, USA | [c] Department of Radiology, Division of Pediatric Radiology, University of Virginia, Charlottesville VA, USA | [d] Department of Pediatrics, Division of Neonatology, University of Virginia, Charlottesville, VA, USA
Correspondence: [*] Correspondence to: Lisa Letzkus, PhD, RN, CPNP-AC, University of Virginia Children’s Hospital, PO BOX 800828, Charlottesville, VA 22908. Tel.: +1 434 924 0245; Fax: +1 434 244 4403; E-mail: lmc8c@uvahealth.org.
Abstract: BACKGROUND:Premature infants are at increased risk for cerebral palsy (CP). Early interventions with a motor focus and administered by parents may improve motor outcomes. AIMS:Secondary study evaluating the short-term motor outcomes and risk for CP in very low birthweight (VLBW) infants randomized to multimodal interventions with a motor focus provided by parents versus usual care. STUDY DESIGN:Randomized controlled trial (intervention vs. usual care (control group)) SUBJECTS:Infants (<32 weeks’ gestational age (GA) and/or <1500 grams birthweight) born between March 2019 and October 2020. OUTCOME MEASURES:Short-term motor outcomes and risk for CP was evaluated using the Hammersmith Infant Neurological Evaluation (HINE, primary motor outcome), the General Movement Assessment (GMA) and the Test of Infant Motor Performance (TIMP) at 3 months’ postmenstrual age (PMA). RESULTS:70 participants were enrolled (GA 28.3±2.7 weeks, birthweight 1139.2±376.6 grams, 64.3% male). The in-person follow-up rate was 73%, lower than expected, in part due to COVID-19 restrictions, resulting in 25 infants (intervention) and 26 infants (control) with outcome data available for analysis. There was not a significant difference in the HINE, GMA or TIMP at 3 months’ PMA between groups. CONCLUSION:Multimodal interventions with a motor focus and provided by parents need further investigation to determine if they can improve short-term motor outcomes in VLBW infants. These interventions are evidence-based and the evaluation of broader implementation into routine care is also needed.
Keywords: Cerebral palsy, early intervention, neonatal intensive care unit, parental engagement, very low birthweight infant
DOI: 10.3233/NPM-230206
Journal: Journal of Neonatal-Perinatal Medicine, vol. 17, no. 5, pp. 637-645, 2024
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl