Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Lasisi, Akeem O. | Olayemi, Oladapo | Tongo, Kemi | Arinola, Olatubosun G. | Bakare, R.A. | Omilabu, S.A.
Affiliations: Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Ibadan, Nigeria | Department of Obstetrics & Gynaecology (Statistics), College of Medicine, University of Ibadan, Ibadan, Nigeria | Department of Paediatrics, College of Medicine, University of Ibadan, Ibadan, Nigeria | Department of Immunology & Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria | Department of Medical Microbiology & Parasitology, College of Medicine, University of Ibadan, Ibadan, Nigeria | Department of Microbiology, University of Lagos, Lagos, Nigeria
Note: [] Corresponding author: O.A. Lasisi, Department of Otorhinolaryngology, Faculty of Clinical Sciences, College of Medicine, University of Ibadan. Tel.: +234 805 536 9593; E-mail: akeemlasisi@gmail.com
Abstract: Objective: The aim of this prospective study is to determine the correlation between early suppurative otitis media (ESOM) and cord blood concentrations of retinol, zinc, immunoglobulin G (Ig G) and interferon Gamma (IFN-γ). Patients and Methods: Cord blood samples were obtained from the umbilical vein after delivery of infants. Serum was extracted and stored at −80°C and analyzed for retinol, zinc, Ig G and interferon Gamma (IFN-γ). These infants were clinically followed for 12–18 months for the development of ESOM. Suppurative OM was defined by the observation of purulent or mucoid otorrhoea at microotoscopy. Results: The study included 186 term infants, of which 69 (37% had at least one episode of ESOM. Of these infants, 40 were males and 29 were females. The age at development of ESOM was 14 ± 6.2 weeks, with a range between 3 weeks and 8 months. The gestational age at birth was 39 ± 0.2 weeks (range=31–43), and birth weight was 3.1 – 0.45 Kg (range=1.25–4.3). The mean neonatal serum concentrations among the cases and control subjects did not differ for Ig G (1180 mg/ml vs. 1370.2 mg/ml, P=0.46), while they differed for retinol (0.95 μg/L vs. 1.08 μg/, P < 0.01), for zinc (0.88 μ g/L vs. 1.05 μ g/L, P=0.01) and for IFN-γ (45.3 pg/ml vs. l70.2 pg/ml, P < 0.01) respectively. Conclusion: We conclude that decreased concentrations of immunobiologic factors in cord blood can be a contributing factor to the development of ESOM in infants during the first year of life.
DOI: 10.3233/NPM-2009-0068
Journal: Journal of Neonatal-Perinatal Medicine, vol. 2, no. 3, pp. 187-192, 2009
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl