Association between SORL1 polymorphisms and the risk of Alzheimer’s disease

Article type: Review Article

Authors: Cong, Lele^a | Kong, Xiangyi^c | Wang, Jing^a | Du, Jianshi^b | Xu, Zhongxin^a | Xu, Yanan^a | Zhao, Qing^{a; *}

Affiliations: [a] Department of Neurology, China–Japan Union Hospital of Jilin University, Changchun, 130033, Jilin Province, China | [b] Department of Vascular Surgery, China–Japan Union Hospital of Jilin University, Changchun, 130033, Jilin Province, China | [c] Institute of Clinical Medicine, Jilin University, Changchun, 130021, China

Correspondence: [*] Corresponding author. E-mail: zhaoqing@jlu.edu.cn.

Abstract: A meta-analysis was performed to identify empirical data assessing the effects of a single nucleotide polymorphisms of sortilin-related receptor on Alzheimer’s disease based on 14 studies involving 37941 cases and 49727 control studies. The results show an increased risk between the single nucleotide polymorphisms (rs641120, rs1010159) and Alzheimer’s disease susceptibility in Asian populations, single nucleotide polymorphisms rs689021 was associated with a decreased risk in Caucasians, and single nucleotide polymorphisms rs641120 was detected as a decreased risk in both populations. Given these data, we provide crucial evidence to manifest that a significant relationship exists between SORL1 polymorphisms and the susceptibility of Alzheimer’s disease.

Keywords: Alzheimer’s disease, single nucleotide polymorphisms, sortilin-related receptor, neurogenomics

DOI: 10.3233/JIN-170051

Journal: Journal of Integrative Neuroscience, vol. 17, no. 2, pp. 239-251, 2018