HDinHD: A Rich Data Portal for Huntington’s Disease Research

Article type: Short Communication

Authors: Aaronson, Jeff^{a; *} | Beaumont, Vahri^a | Blevins, Richard A.^b | Andreeva, Viktoria^c | Murasheva, Irina^c | Shneyderman, Anastasia^{c; 1} | Armah, Kabenla^c | Gill, Rob^c | Chen, Jian^a | Rosinski, Jim^a | Park, Larry C.^{a; 2} | Coppola, Giovanni^d | Munoz-Sanjuan, Ignacio^a | Vogt, Thomas F.^a

Affiliations: [a] CHDI Management/CHDI Foundation, Princeton, NJ, USA | [b] Bridlewood Consulting LLC, Flower Mound, TX, USA | [c] Rancho Biosciences LLC, San Diego, CA, USA | [d] Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA

Correspondence: [*] Correspondence to: Jeff Aaronson, CHDI Management/CHDI Foundation, 155 Village Boulevard, Suite 200, Princeton, NJ 08540, USA. Tel.: +1 609 945 9616; E-mail: Jeff.Aaronson@chdifoundation.org.

Note: [1] Present address: Insilico Medicine Hong Kong Limited, Pak Shek Kok, Hong Kong

Note: [2] Present address: Naason Science Inc., KBIO New Drug Development Center, Osong-eup, Cheongju-si, Korea

Abstract: HDinHD (Huntington’s Disease in High Definition; HDinHD.org) is an open online portal for the HD research community that presents a synthesized view of HD-related scientific data. Here, we present a broad overview of HDinHD and highlight the newly launched HDinHD Explorer tool that enables researchers to discover and explore a wide range of diverse yet interconnected HD-related data. We demonstrate the utility of HDinHD Explorer through data mining of a single collection of newly released in vivo therapeutic intervention study reports alongside previously published reports.

Keywords: HDinHD, Huntington’s disease in high definition, data dissemination, rolipram

DOI: 10.3233/JHD-210491

Journal: Journal of Huntington's Disease, vol. 10, no. 3, pp. 405-412, 2021