Affiliations: [a] Field Neurosciences Institute for Restorative Neurology, Central Michigan University, Mount Pleasant, MI, USA
| [b] Program in Neuroscience, Central Michigan University, Mount Pleasant, MI, USA
| [c] Department of Psychology, Central Michigan University, Mount Pleasant, MI, USA
| [d] College of Medicine, Central Michigan University, Mount Pleasant, MI, USA
| [e]
Field Neurosciences Institute, St. Mary’s of Michigan, Saginaw, MI, USA
Correspondence:
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Correspondence to: Gary L. Dunbar, Psychology/Neuroscience Program, Health Professions 2182, Central Michigan University, Mount Pleasant, MI 48859, USA. E-mail: dunba1g@cmich.edu.
Abstract: The R6/2 murine model of Huntington’s disease (HD) is extensively used in HD research. The current study replicates and extends previous work assessing the impact of housing R6/2 mice with healthy wild-type (WT) littermates on disease progression. The current study extends the previous finding by including male cohorts and the use of a standard diet and water regimen, as opposed to the enhanced diet used in the previous study. This study found that the inclusion of healthy wild-type (WT) littermates, alone, improved survivabilty in R6/2 mice, but did not have a significant impact on weight loss.