Pilot Validation of Ambulatory Activity Monitors for Sleep Measurement in Huntington’s Disease Gene Carriers

Article type: Research Article

Authors: Maskevich, Svetlana^{a; b} | Jumabhoy, Ria^a | Dao, Pierre D.M.^a | Stout, Julie C.^{a; b; *} | Drummond, Sean P.A.^{a; b}

Affiliations: [a] School of Psychological Sciences, Monash University, Melbourne, Australia | [b] Monash Institute of Cognitive and Clinical Neurosciences, Melbourne, Australia

Correspondence: [*] Correspondence to: Professor Julie Stout, Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Faculty of Nursing, Medicine, and Health Sciences, Monash University, Clayton, VIC 3800, Australia. Tel.: +61 3 9905 3987; Fax: +61 3 9905 3984; E-mail: Julie.Stout@monash.edu.

Abstract: Sleep disturbance occurs early in Huntington’s disease (HD). Consumer- and research-grade activity monitors may enable routine assessment of sleep disturbances in HD. We compared Actiwatch Spectrum Pro, Jawbone UP2 and Fitbit One to the gold standard, polysomnography, in four late presymptomatic and three early HD participants. Compared to polysomnography, all ambulatory monitors overestimated total sleep time by >60 minutes and sleep efficiency by ∼15%. Thus, for assessment of specific sleep parameters in HD, none of the activity monitors are sufficiently accurate to replace polysomnography, although they may be sufficient for estimating overall sleep-wake patterns. Larger sample replication is required.

Keywords: Huntington’s disease, sleep, actigraphy, ambulatory monitoring, validation

DOI: 10.3233/JHD-170251

Journal: Journal of Huntington's Disease, vol. 6, no. 3, pp. 249-253, 2017