Digital holographic microscopy of highly sensitive living cells

Article type: Research Article

Authors: Yang, Shuntao

Affiliations: Information Technology Department, Guangxi Transport Vocational and Technical College, Nanning, Guangxi 530023, China | E-mail: m13877171975@163.com

Correspondence: [*] Corresponding author: Information Technology Department, Guangxi Transport Vocational and Technical College, Nanning, Guangxi 530023, China. E-mail: m13877171975@163.com.

Abstract: In order to solve the problem that the existing living cell microscopy technology can not display the detailed information of cells, a high sensitivity digital holographic living cell microscopy technology is proposed in this paper. By measuring the phase distribution and refractive index distribution of living cells, the data of living cells are extracted and converted into digital hologram of living cells. Simulation and comparison of the commonly used two-dimensional living cell microscope methods. The experimental results show that the high-sensitivity digital holographic microscopic detection method can obtain the detailed information of living cells, which proves the effectiveness of this study.

Keywords: High sensitivity, bioactive cells, digital holography, microscopy, cellular, electron microscopy, adsorption, cell-surface interaction, biological, refractive index

DOI: 10.3233/JCM215504

Journal: Journal of Computational Methods in Sciences and Engineering, vol. 21, no. 6, pp. 1985-1997, 2021