Correlation Analysis of ApoB, ApoA1, and ApoB/ApoA1 with Cortical Morphology in Patients with Memory Complaints

Article type: Research Article

Authors: Wang, Jiayu^{a; b; c} | Xu, Lisi^{a; b} | Chen, Xuemei^{a; b} | Wu, Jiajing^{a; b; c} | Chen, Yu^{a; d} | Feng, Ziqian^{a; b; c} | Dong, Li^{a; e; f} | Yao, Dezhong^{a; e; f} | Cai, Qingyan^{a; b} | Jian, Wei^{a; b} | Li, Hongyi^{a; b} | Duan, MingJun^{a; b; *} | Wang, Ziqi^{a; b; *}

Affiliations: [a] The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China | [b] Department of Geriatrics, the Fourth People’s Hospital of Chengdu, Chengdu, China | [c] Nursing School of Zunyi Medical University, Zunyi, China | [d] Department of Radiology, the Fourth People’s Hospital of Chengdu, Chengdu, China | [e] Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, Chengdu, China | [f] Sichuan Institute for Brain Science and Brain-Inspired Intelligence, Chengdu, China

Correspondence: [*] Correspondence to: Ziqi Wang and MingJun Duan, The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China. E-mails: ziqiwang@foxmail.com and fourhospital@163.com.

Abstract: Background:Apolipoproteins and cortical morphology are closely associated with memory complaints, and both may contribute to the development of Alzheimer’s disease. Objective:To examine whether apolipoprotein B (ApoB), apolipoprotein A-1 (ApoA1), and their ratio (ApoB/ApoA1) are associated with cortical morphology in patients with memory complaints. Methods:Ninety-seven patients underwent neuropsychological testing, measurements of ApoB, ApoA1, ApoB/ApoA1, plasma Alzheimer’s biomarker, apolipoprotein E (ApoE) genotyping, and 3T structural magnetic resonance imaging (sMRI) scans. Based on sMRI scanning locations, patients were categorized into the University of Electronic Science and Technology (UESTC) and the Fourth People’s Hospital of Chengdu (FPHC). The Computational Anatomy Toolbox within Statistical Parametric Mapping was used to calculate each patient’s cortical morphology index based on sMRI data. The cortical morphology index and apolipoproteins were also analyzed. Results:Significant positive correlations were found between ApoB and sulcal depth in the lateral occipital cortex among the UESTC, the FPHC, and the total sample groups, and negative correlations were observed between sulcal depth in the lateral occipital cortex and the scores of the Shape Trails Test Part A and B. In the FPHC group, the scores of the Montreal Cognitive Assessment Basic, delayed recall of the Auditory Verbal Learning Test, Animal Fluency Test and Boston Naming Test were positively correlated with the sulcal depth. Conclusions:ApoB is associated with the sulcal depth in the lateral occipital cortex, potentially relating to speed/executive function in individuals with memory complaints.

Keywords: Alzheimer’s disease, ApoB, lateral occipital cortex, memory complaints, sulcal depth

DOI: 10.3233/JAD-230863

Journal: Journal of Alzheimer's Disease, vol. 101, no. 4, pp. 1137-1150, 2024