Affiliations: Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan
Correspondence:
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Correspondence to: I-Shiang Tzeng, No. 289, Jianguo Rd., Xindian Dist., New Taipei City 231, Taiwan. Tel.: +886 2 6628 9779; E-mail: istzeng@gmail.com.
Abstract: Akada et al. conducted a nationwide database study on patients with Alzheimer’s disease, examining risk factors and outcomes over 3 years. A significant association emerged between decreased daily activities and hip fractures. However, the odds ratio was 1.95 (with p = 0.020) may be inaccurate in men, considering the wide 95% confidence interval (1.12–3.51). Possible influencing factors include an inappropriate outcome variable, sparse-data bias, collinear covariates, and comorbidities. Moreover, exact propensity-score matching would be more efficient than nested matching. Limitations include potential recall bias in measuring daily activities and limited applicability of cause-effect relationships in a national database study.
