Affiliations: [a] Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
| [b] Open Innovation Laboratory for Food and Medicinal Resource Engineering (FoodMed-OIL), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan
| [c] Doctoral Program in Physical Education, Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
| [d] Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
| [e] Alliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, Tsukuba, Ibaraki, Japan
| [f] Institute of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
Correspondence:
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Correspondence to: Jieun Yoon, Institute of Health and Sport Sciences, University of Tsukuba, 1-2 Kasuga, Tsukuba, Ibaraki, Japan. Tel.: +81 29 859 1593; E-mail: yoon.jieun.fu@u.tsukuba.ac.jp.
Abstract: Background:The amyloid-β1-42 (Aβ42) level is a biomarker that is widely used to evaluate individual cognitive dysfunction early in neurodegenerative diseases, as well as differentiate between normal cognitive function, mild cognitive impairment, Alzheimer’s disease, and vascular cognitive impairment. Objective:Our cross-sectional study evaluated the association between daily exercise and physical and cognitive function and Aβ42 levels among a subsample of 325 older adults from the Kasama Study. Methods:Participants (age: 74.5 [range 65–90] years) were classified into three exercise groups: the dual-task (DEG, n = 128), single-task (SEG, n = 122), and non-exercise (NEG, n = 75) groups. The main outcomes were the plasma Aβ42 levels and the scores of the five cognitive (5-COG) tests and five cognition-related physical function (5-PHYS) tests. Results:The Aβ42 levels and 5-COG and 5-PHYS scores were higher in the SEG and DEG than in the NEG. The Aβ42 levels were higher in the DEG than in the NEG (p = 0.008). Conclusions:Physical activities such as regular exercise may benefit older adults, improving their cognitive and physical function.
