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Article type: Article Commentary
Authors: Cheng, Chenga; b; c | Yang, Cuid | Jia, Congcongc | Wang, Qingshana; b; *
Affiliations: [a] School of Public Health, Dalian Medical University, Dalian, China | [b] National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, China | [c] Liaoning Provincial Key Laboratories for Research on the Pathogenic Mechanisms of Neurological Diseases, the First Affiliated Hospital of Dalian Medical University, Dalian, China | [d] Institute of Neurology, Sichuan Academy of Medical Sciences-Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Correspondence: [*] Correspondence to: Qingshan Wang, PhD, Professor, School of Public Health, Dalian Medical University, Dalian, 116044, China; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, 116044, China. E-mail: wangq4@126.com.
Abstract: Alzheimer’s disease (AD) is a complex, heterogeneous, and progressive neurodegenerative dementia. Although the majority of AD research has primarily focused on disease-associated alterations of the cortex and hippocampus in the cerebrum, emerging evidence has highlighted the cerebellum’s involvement in sleep, cognition, and AD. In this commentary, we discuss a recently published article in Alzheimer’s and Dementia, which examines changes in cerebellar electrophysiology, sleep-wake cycles, and neuropathology in APPswe/PS1ΔE9 mice. We also explore the potential role of the cerebellum in AD, offering a fresh perspective on the study of cerebellar involvement in the disease.
Keywords: Alzheimer’s disease, cerebellum, electroencephalogram, neuropathology, sleep disturbances
DOI: 10.3233/JAD-230381
Journal: Journal of Alzheimer's Disease, vol. 95, no. 1, pp. 75-78, 2023
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