The PI3K/AKT Signaling Pathway and Caspase-3 in Alzheimer’s Disease: Which One Is the Beginner?

Article type: Article Commentary

Authors: Khezri, Mohammad Rafi^a | Ghasemnejad-Berenji, Morteza^{b; c; *} | Moloodsouri, Donya^a

Affiliations: [a] Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran | [b] Research Center for Experimental and Applied Pharmaceutical Sciences, Urmia University of Medical Sciences, Urmia, Iran | [c] Department of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran

Correspondence: [*] Correspondence to: Dr. Morteza Ghasemnejad-Berenji, Assistant Professor of Pharmacology, Department of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran. E-mail: ghasemnejad.m@umsu.ac.ir; ORCID: orcid.org/0000-0001-5672-9202

Abstract: One of the main players in apoptosis during Alzheimer’s disease progression are different members of caspase family of proteases. The most well-known member of this family is caspase-3, in which alterations of its levels have been detected in samples from Alzheimer’s disease patients. There are numerous intracellular factors involved in regulation of cellular apoptosis through regulation of caspase-3 activity, the most important of which is the PI3K/AKT signaling pathway. This commentary tries to highlight the probable relations between PI3K/AKT signaling pathway and caspase-3 in Alzheimer’s disease.

Keywords: Alzheimer’s disease, apoptosis, caspase-3, PI3K/AKT

DOI: 10.3233/JAD-221157

Journal: Journal of Alzheimer's Disease, vol. 92, no. 2, pp. 391-393, 2023