Preliminary Analysis of Volume-Based Resting-State Functional MRI Characteristics of Successful Aging in China

Article type: Research Article

Authors: Sun, Jiaojiao^{a; b; 1} | Zhao, Xingfu^{a; 1} | Zhou, Jianbang^c | Dang, Xinghong^c | Zhu, Shenglong^c | Liu, Liang^{a; *} | Zhou, Zhenhe^{a; *}

Affiliations: [a] Department of Geriatric Psychiatry, Wuxi Mental Health Center, Nanjing Medical University, Wuxi, Jiangsu, China | [b] Department of General Psychiatry, Yangzhou Wutaishan Hospital, Yangzhou, Jiangsu, China | [c] Department of Psychiatry, Haidong First People’s Hospital, Haidong, Qinghai, China

Correspondence: [*] Correspondence to: Liang Liu, MD, PhD, Department of Geriatric Psychiatry, Wuxi Mental Health Center, Nanjing Medical University, Wuxi, Jiangsu, 214151, China. Tel.: +86 510 83250527; E-mail: liuliangwx@163.com. and Zhenhe Zhou, MD, PhD, Department of Geriatric Psychiatry, Wuxi Mental Health Center, Nanjing Medical University, Wuxi, Jiangsu, 214151, China. Tel.: +86 510 83200162; E-mail: zhouzh@njmu.edu.cn.

Note: [1] These authors contributed equally to this work.

Abstract: Background:Resting-state function MRI (rs-fMRI) research on successful aging can provide insight into the mechanism of aging with a different perspective from aging-related disease. Objective:rs-fMRI research was used to analyze the brain function characteristics of successful aging. Methods:A total of 47 usual aging individuals and 26 successful aging (SA) individuals underwent rs-fMRI scans and neuropsychological tests. Volume-based rs-fMRI data analysis was performed with DPASF to obtain ALFF, ReHo, DC, and VMHC. Results:The SA group showed increased ALFF in right opercular part of inferior frontal gyrus (Frontal_Inf_Oper_R) and right supramarginal gyrus; increased ReHo in right middle temporal pole gyrus and decreased ReHo in left superior frontal gyrus and middle occipital gyrus; increased DC in right medial orbitofrontal gyrus and pulvinar part of thalamus; decreased DC in left fusiform gyrus and right medial frontal gyrus; increased VMHC in right medial orbitofrontal gyrus; and decreased VMHC in the right superior temporal gyrus, right and left middle temporal gyrus, right and left triangular part of inferior frontal gyrus. ALFF in Frontal_Inf_Oper_R were found to be significantly correlated with MMSE scores (r = 0.301, p = 0.014) and ages (r = –0.264, p = 0.032) in all subjects, which could be used to distinguish the SA (AUC = 0.733, 95% CI: 0.604–0.863) by ROC analysis. Conclusion:The brain regions with altered fMRI characteristics in SA group were concentrated in frontal (6 brain regions) and temporal (4 brain regions) lobes. ALFF in Frontal_Inf_Oper_R was significantly correlated to cognitive function and ages, which might be used to distinguish the SA.

Keywords: Amplitude of low frequency fluctuations, degree centrality, regional homogeneity, resting-state fMRI, successful aging, voxel-mirrored homotopic connectivity

DOI: 10.3233/JAD-220780

Journal: Journal of Alzheimer's Disease, vol. 91, no. 2, pp. 767-778, 2023