Correlation Between Plasma Oligomeric Amyloid-β and Performance on the Language Neutral Visual Cognitive Assessment Test in a Southeast Asian Population

Article type: Short Communication

Authors: Sandhu, Gurveen Kaur^a | Zailan, Fatin Zahra^a | Vipin, Ashwati^a | Ann, Soo See^a | Kumar, Dilip^a | Ng, Kok Pin^{a; b; c} | Kandiah, Nagaendran^{a; *}

Affiliations: [a] Lee Kong Chian School of Medicine, Singapore | [b] National Neuroscience Institute, Singapore | [c] Duke-NUS Medical School, Singapore

Correspondence: [*] Correspondence to: Associate Professor Nagaendran Kandiah, Lee Kong Chian School of Medicine, 11 Mandalay Rd, 308232, Singapore. Tel.: +65 65922653; E-mail: nagaendran_kandiah@ntu.edu.sg.; ORCID: 0000-0001-9244-4298

Abstract: Oligomeric amyloid-β (OAβ), an upstream driver of Alzheimer’s disease (AD) neuropathology, correlates with poor cognitive performance and brain volume reduction. Its effect on cognitive performance measured by the language neutral Visual Cognitive Assessment Test (VCAT) remains to be evaluated. We studied the correlation of plasma OAβ with VCAT scores and grey matter volume (GMV) in a Southeast Asian cohort with mild cognitive impairment. Higher plasma OAβ significantly correlated with lower; cognitive scores (VCAT, Mini-Mental State Examination) and GMV/intracranial volume ratio. Such findings reveal the clinical utility of plasma OAβ as a promising biomarker and support validation through longitudinal studies.

Keywords: Alzheimer’s disease, cognitive assessment, cross sectional study, grey matter volume, mild cognitive impairment, Mini-Mental State Examination, multimer detection system, oligomeric amyloid-beta, plasma biomarkers, Visual Cognitive Assessment Test

DOI: 10.3233/JAD-220484

Journal: Journal of Alzheimer's Disease, vol. 89, no. 1, pp. 25-29, 2022