Affiliations: [a] Unit of Geriatrics, Campus Bio-Medico University of Rome, Rome, Italy
| [b] Department of Medicine and Surgery, Section of Gerontology and Geriatrics, University of Perugia, Perugia, Italy
| [c] Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet Stockholm, Stockholm, Sweden
Correspondence:
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Correspondence to: Diana Lelli, Unit of Geriatrics, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 200, 00128 Roma, Italy. Tel.: +39 6225411454; Fax: +39 622541456; E-mail: d.lelli@policlinicocampus.it.
Abstract: Background:Dementia is a risk factor for undernutrition. However, it is not clear if specific cognitive deficits have a higher risk of undernutrition and how much appetite/nutritional problems and caregiver stress mediate this association. Objective:To evaluate the relationship between nutritional status and severity of global and function-specific scores of cognitive dysfunctions, and to which extent this association is mediated by appetite/nutritional problems and caregiver stress. Methods:Cross-sectional analysis of the ReGAl study data, including 761 older adults attending a Memory Clinic. Nutritional status was evaluated with Mini Nutritional Assessment (MNA). The relationship between scores at neuro-cognitive tests and risk of undernutrition was evaluated using logistic regression models adjusted for potential confounders. To allow comparison between different tests, all scores were standardized. Mediation analysis was used to evaluate how much appetite/nutritional problems and caregiver stress mediate this association. Results:Mean age was 77 years (SD: 9), 37.3% were women. Exploring different cognitive domains, a stronger association was documented for attentive matrices (OR:0.49, 95% CI: 0.34–0.72), the figure copy test (OR:0.63, 95% CI: 0.45–0.88), and the verbal judgement test (OR:0.61, 95% CI: 0.42–0.91). The proportion of the effect of cognition (MMSE) on nutritional status mediated by caregiver distress was 9.5% (95% CI: 0.002–0.27), the proportion mediated by appetite/nutritional problems was 11% (95% CI: –4.8–3.18). Conclusion:Risk of undernutrition is associated to cognitive decline; a stronger association was observed for attention, praxis, and reasoning. Caregiver distress is a mediator of this association. This information should be considered in the management plans of this population.
Keywords: Appetite alteration, caregiver burden, dementia, malnutrition, Mini Nutritional Assessment
