Affiliations: [a]
Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA
| [b]
Institute of Public Health, Washington University in St. Louis, St. Louis, MO, USA
| [c]
Department of Psychology, Faculty of Humanities, University of Johannesburg, Johannesburg, South Africa
| [d]
Department of Clinical Research and Leadership, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA
| [e] Division of Biostatistics, Washington University in St. Louis, St. Louis, MO, USA
| [f]
Center for Clinical Studies, Washington University in St. Louis, St. Louis, MO, USA
Correspondence:
[*]
Correspondence to: Ganesh M. Babulal, OTD, PhD, Department of Neurology, Washington University in Saint Louis School of Medicine, 660 Euclid Ave., CB 8111, St. Louis, MO 63110, USA. Tel.: +1 314 286 2435; E-mail: babulalg@wustl.edu.
Abstract: Alzheimer’s disease (AD) studies in cognitively normal (CN) older adults age≥65 suggest depression is associated with molecular biomarkers (imaging and cerebrospinal fluid [CSF]). This study used linear mixed models (covariance pattern model) to assess whether baseline CSF biomarkers (Aβ42/Aβ40, t-Tau/Aβ42, p-Tau/Aβ42) predicted changes in non-depressed mood states in CN older adults (N = 248), with an average of three follow-up years. Participants with higher levels of CSF biomarkers developed more anger, anxiety, and fatigue over time compared to those with more normal levels. Non-depressed mood states in preclinical AD may be a prodrome for neuropsychiatric symptoms in symptomatic AD.
