Difference in Amyloid Load Between Single Memory Domain and Multidomain Subjective Cognitive Decline: A Study from the SILCODE

Article type: Research Article

Authors: Wang, Xiaoqi^a | Bi, Qiuhui^b | Lu, Jie^c | Chan, Piu^{a; d} | Hu, Xiaochen^e | Su, Li^{f; g} | Jessen, Frank^{e; h; i} | Lin, Hua^a | Han, Chunlei^j | Shu, Ni^{b; *} | Liu, Hesheng^{k; *} | Han, Ying^{a; d; l; m; *}

Affiliations: [a] Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China | [b] State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China | [c] Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China | [d] National Clinical Research Center for Geriatric Disorders, Beijing, China | [e] Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany | [f] Department of Psychiatry, University of Cambridge, United Kingdom | [g] Sino-Britain Centre for Cognition and Ageing Research, Southwest University, Chongqing, China | [h] German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany | [i] Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Germany | [j] Turku PET Centre, Turku, Finland | [k] Athinlula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA | [l] Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China | [m] School of Biomedical Engineering, Hainan University, Haikou, China

Correspondence: [*] Correspondence to: Ying Han, Department of Neurology, Xuanwu Hospital of Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing 100053, China. Tel.: +86 13621011941; E-mail: hanying@xwh.ccmu.edu.cn and Hesheng Liu, Athinlula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. Tel.: +1 617 643 7460; E-mail: Hesheng@nmr.mgh.harvard.edu and Ni Shu, State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, No.19 Xinjiekouwai Street, Haidian District, Beijing 100875, China. Tel.: +86 15801582918; E-mail: nshu@bnu.edu.cn.

Abstract: Background:Subjective cognitive decline (SCD), an at-risk condition of Alzheimer’s disease (AD), can involve various cognitive domains, such as memory, language, planning, and attention. Objective:We aim to explore the difference in amyloid load between the single memory domain SCD (sd-SCD) and the multidomain SCD (md-SCD) and assess the relationship of amyloid pathology with quantitative SCD scores and objective cognition. Methods:A total of 63 SCD participants from the SILCODE study underwent the clinical evaluation, neuropsychological assessment, and 18F-florbetapir PET scan. Global amyloid standard uptake value ratio (SUVr) was calculated. Additionally, regional amyloid SUVr was quantified in 12 brain regions of interests. A nonparametric rank ANCOVA was used to compare the global and regional amyloid SUVr between the md-SCD (n = 34) and sd-SCD (n = 29) groups. A multiple linear regression analysis was conducted to test the relationship of amyloid SUVr with quantitative SCD scores and objective cognition. Results:Compared with individuals with sd-SCD, individuals with md-SCD had increased global amyloid SUVr (F = 5.033, p = 0.029) and regional amyloid SUVr in the left middle temporal gyrus (F = 12.309, p = 0.001; Bonferroni corrected), after controlling for the effects of age, sex, and education. When pooling all SCD participants together, the increased global amyloid SUVr was related with higher SCD-plus sum scores and lower Auditory Verbal Learning Test-delayed recall scores. Conclusion:According to our findings, individuals with md-SCD showed higher amyloid accumulation than individuals with sd-SCD, suggesting that md-SCD may experience a more advanced stage of SCD. Additionally, increased global amyloid load was predictive of a poorer episodic memory function in SCD individuals.

Keywords: Alzheimer’s disease, amyloid, multidomain, single memory domain, subjective cognitive decline

DOI: 10.3233/JAD-215373

Journal: Journal of Alzheimer's Disease, vol. 85, no. 4, pp. 1573-1582, 2022