Affiliations: [a]
Heilongjiang University of Chinese Medicine, Harbin, China
| [b]
First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China
Correspondence:
[*]
Correspondence to: Dr. Xin Fu, School of Pharmacy, Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Harbin 150040, China. E-mail: fu13796063704@sina.com.
Note: [1] These authors contributed equally to this work.
Abstract: Alzheimer’s disease (AD) is a common progressive neurodegenerative disease. In recent years, the research on the treatment of AD with Chinese medicine is increasing and the results are optimistic, which may provide some new options for the treatment of AD. Existing animal and clinical studies have found that Danggui Shaoyao San (DSS), which has been used in gynecological diseases, is effective in the treatment of AD. As the main component of DSS, macromolecular polysaccharide plays an indispensable role in the treatment of AD. In addition to anti-inflammatory, anti-neuronal injury, and immune regulation, polysaccharides extracted from Danggui Shaoyao San (p-DSS) also have good activities in hypoglycemia, and participate in the physiological regulation of ubiquitination, iron metabolism, intestinal flora, estrogen, and autophagy. Given that there is little systematic analysis of p-DSS, this paper reviews the possible mechanism of p-DSS in the treatment of AD, so as to provide reference for further research.
Keywords: Alzheimer’s disease, estrogens, hypoglycemic, intestinal flora, iron metabolism, polysaccharides of Danggui-Shaoyao-San
