Greek High Phenolic Early Harvest Extra Virgin Olive Oil Reduces the Over-Excitation of Information-Flow Based on Dominant Coupling Mode (DoCM) Model in Patients with Mild Cognitive Impairment: An EEG Resting-State Validation Approach

Article type: Research Article

Authors: Dimitriadis, Stavros I.^{a; b; c; d; e; f; g; h; i; *} | Lyssoudis, Christos^b | Tsolaki, Anthoula C.^a | Lazarou, Eftychia^b | Kozori, Mahi^b | Tsolaki, Magda^{a; b}

Affiliations: [a] 1st Department of Neurology, G.H. “AHEPA, ” School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki (AUTH), Thessaloniki, Greece | [b] Greek Association of Alzheimer’s Disease and Related Disorders, Thessaloniki, Makedonia, Greece | [c] Integrative Neuroimaging Lab, Thessaloniki, Greece | [d] Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, College of Biomedical and Life Sciences, Cardiff University, Cardiff, Wales, United Kingdom | [e] Neuroinformatics Group, Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, College of Biomedical and Life Sciences, Cardiff, Wales, United Kingdom | [f] Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, College of Biomedical and Life Sciences, Cardiff University, Cardiff, Wales, United Kingdom | [g] School of Psychology, College of Biomedical and Life Sciences, Cardiff University, Cardiff, Wales, United Kingdom | [h] Neuroscience and Mental Health Research Institute, School of Medicine, College of Biomedical and Life Sciences, Cardiff University, Cardiff, Wales, United Kingdom | [i] MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, College of Biomedical and Life Sciences, Cardiff University, Cardiff, Wales, United Kingdom

Correspondence: [*] Correspondence to: Stavros I. Dimitriadis, Division of Psychological Medicine and Clinical Neurosciences, School of Medi-cine, College of Biomedical and Life Sciences, Cardiff University,CF24 4HQ, Cardiff, Wales, United Kingdom. E-mails: DimitriadisS@cardiff.ac.uk and stidimitriadis@gmail.com.

Abstract: Background:Extra virgin olive oil (EVOO) constitutes a natural compound with high protection over cognitive function that could positively alter brain dynamics and the mixture of within and between-frequency connectivity. Objective:The balance of cross-frequency coupling over within-frequency coupling can build a nonlinearity index (NI) that encapsulates the over-excitation of information flow between brain areas and across experimental time. The present study investigated for the very first time how the Greek High Phenolic Early Harvest Extra Virgin Olive Oil (HP-EH-EVOO) versus Moderate Phenolic (MP-EVOO) and Mediterranean Diet (MeDi) intervention in people with mild cognitive impairment (MCI) could affect their spontaneous EEG dynamic connectivity. Methods:Forty-three subjects (14 in MeDi, 16 in MP-EVOO, and 13 in HP-EH-EVOO) followed an EEG resting-state recording session (eyes-open and closed) before and after the treatment. Following our dominant coupling mode model, we built a dynamic integrated dynamic functional connectivity graph that tabulates the functional strength and the dominant coupling mode model of every pair of brain areas. Results:Signal spectrum within 1–13 Hz and theta/beta ratio have decreased in the HP-EH-EVOO group in the eyes-open condition. The intervention improved the FIDoCM across groups and conditions but was more prominent in the HP-EH-EVOO group (p < 0.001). Finally, we revealed a significant higher post-intervention reduction of NI (ΔNITotal and α) for the HP-EH-EVOO compared to the MP-EVOO and MeDi groups (p < 0.0001). Conclusion:Long-term intervention with HP-EH-EVOO reduced the over-excitation of information flow in spontaneous brain activity and altered the signal spectrum of EEG rhythms.

Keywords: Alzheimer’s disease, chronnectomics, cross-frequency coupling, EEG, extra virgin olive oil, mediterranean diet, mild cognitive impairment, multiplexity, non-pharmaceutical interventions

DOI: 10.3233/JAD-210454

Journal: Journal of Alzheimer's Disease, vol. 83, no. 1, pp. 191-207, 2021