Affiliations: [a]
Departments of Medicine, University of Montreal, Montreal, Quebec, Canada
| [b]
Research Centre of the Geriatric University Institute of Montreal, Montreal, Quebec, Canada
| [c]
Department of Medicine, Division of Geriatric Medicine, Sir Mortimer B. Davis Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
| [d]
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
| [e]
Research Center of the Centre Hospitalier de l’Université de Montreal, Montreal, Quebec, Canada
| [f] Division of Geriatric Medicine, McGill University Health Centre, Montreal, Quebec, Canada
| [g]
Department of Neurology, Geneva University Hospital and University of Geneva, Switzerland
Correspondence:
[*]
Correspondence to: Olivier Beauchet, MD, PhD, Research Centre of the Geriatric University Institute of Montreal, Montreal, Quebec, Canada. Tel.: +1 514 340 3540, # 3637; Fax: +1 514 340 4765; E-mail: olivier.beauchet@umontreal.ca.
Abstract: Background:Motoric cognitive risk syndrome (MCR) and mild cognitive impairment (MCI) are two pre-dementia stages with an overlap, which may influence the risk for dementia. Objective:The study aims to examine the association of MCR, MCI, and their combination with incident dementia in Quebec community-dwelling older adults. Methods:1,063 older adults (i.e., ≥65) were selected from a population-based observational cohort study known as the “Nutrition as a determinant of successful aging: The Quebec longitudinal study” (NuAge). Participants were separated into four groups at the baseline assessment: those without MCR and MCI (i.e., cognitively healthy individual; CHI), those with MCR alone, those with MCI alone, and those with MCR plus MCI. Incident dementia was recorded at each annual visit during a 3-year follow-up. Results:The prevalence of CHI was 87.2%, MCR 3.0%, MCI 8.8%, and MCR plus MCI 0.9%. The overall incidence of dementia was 2.4% and was significantly associated with MCR alone (Odd Ratio (OR) = 5.00 with 95% Confidence interval (CI) = [1.01;24.59] and p = 0.049), MCI alone (OR = 6.04 with 95% CI = [2.36;15.47] and p≤0.001), and the combination of MCR and MCI (OR = 25.75 with 95% CI = [5.32;124.66] and p≤0.001). Conclusion:Combining MCR and MCI increased the risk for incident dementia. These results also demonstrated that this combination is a better predictor of dementia than MCI or MCR alone.
