Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Graff-Radford, Jonathana; * | Lesnick, Timothy G.b | Mielke, Michelle M.a; b | Constantopoulos, Elenic | Rabinstein, Alejandro A.a | Przybelski, Scott A.b | Vemuri, Prashanthid | Botha, Hugoa | Jones, David T.a | Ramanan, Vijay K.a | Petersen, Ronald C.a | Knopman, David S.a | Boeve, Bradley F.a | Murray, Melissa E.f | Dickson, Dennis W.f | Jack, Clifford R.d | Kantarci, Kejald | Reichard, R. Rossc
Affiliations: [a] Department of Neurology, Mayo Clinic, Rochester, MN, USA | [b] Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA | [c] Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN, USA | [d] Department of Radiology, Mayo Clinic, Rochester, MN, USA | [e] Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, USA | [f] Department of Pathology and Laboratory Medicine, Mayo Clinic, Jacksonville, FL, USA
Correspondence: [*] Correspondence to: Jonathan Graff-Radford, MD, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Tel.: +1 507 284 2511; Fax: +1 507 538 6012; E-mail: graff-radford.jonathan@mayo.edu.
Abstract: Background:The relationship between cerebral microbleeds (CMBs) on hemosiderin-sensitive MRI sequences and cerebral amyloid angiopathy (CAA) remains unclear in population-based participants or in individuals with dementia. Objective:To determine whether CMBs on antemortem MRI correlate with CAA. Methods:We reviewed 54 consecutive participants with antemortem T2*GRE-MRI sequences and subsequent autopsy. CMBs were quantified on MRIs closest to death. Autopsy CAA burden was quantified in each region including leptomeningeal/cortical and capillary CAA. By a clustering approach, we examined the relationship among CAA variables and performed principal component analysis (PCA) for dimension reduction to produce two scores from these 15 interrelated predictors. Hurdle models assessed relationships between principal components and lobar CMBs. Results:MRI-based CMBs appeared in 20/54 (37%). 10 participants had ≥2 lobar-only CMBs. The first two components of the PCA analysis of the CAA variables explained 74% variability. The first rotated component (RPC1) consisted of leptomeningeal and cortical CAA and the second rotated component of capillary CAA (RPC2). Both the leptomeningeal and cortical component and the capillary component correlated with lobar-only CMBs. The capillary CAA component outperformed the leptomeningeal and cortical CAA component in predicting lobar CMBs. Both capillary and the leptomeningeal/cortical components correlated with number of lobar CMBs. Conclusion:Capillary and leptomeningeal/cortical scores correlated with lobar CMBs on MRI but lobar CMBs were more closely associated with the capillary component. The capillary component correlated with APOE ɛ4, highlighting lobar CMBs as one aspect of CAA phenotypic diversity. More CMBs also increase the probability of underlying CAA.
Keywords: Alzheimer’s disease, capillaries, cerebral amyloid angiopathy, neuropathology
DOI: 10.3233/JAD-201536
Journal: Journal of Alzheimer's Disease, vol. 81, no. 1, pp. 113-122, 2021
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl