Hippocampal Volume and Amyloid PET Status Three Years After Ischemic Stroke: A Pilot Study

Article type: Short Communication

Authors: Brodtmann, Amy^{a; b; c; d; *} | Khlif, Mohamed Salah^a | Bird, Laura J.^a | Cumming, Toby^a | Werden, Emilio^a

Affiliations: [a] The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia | [b] Department of Neurology, Austin Health, Heidelberg, VIC, Australia | [c] Department of Neurology, Royal Melbourne Hospital, Parkville, VIC, Australia | [d] Eastern Cognitive Disorders Clinic, Box Hill Hospital, Monash University, Box Hill, VIC, Australia

Correspondence: [*] Correspondence to: Amy Brodtmann, Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, 245 Burgundy Street, Heidelberg 3084, Australia. Tel.:+61390357004; Fax:+61390357303; E-mail: agbrod@unimelb.edu.au.

Abstract: Hippocampal atrophy is seen in many neurodegenerative disorders and may be a cardinal feature of vascular neurodegeneration. We examined hippocampal volume (HV) in a group of ischemic stroke survivors with amyloid 18F-NAV4694 PET imaging three years after stroke. We compared HV between the amyloid-positive (n = 4) and amyloid-negative (n = 29) groups, and associations with co-morbidities using Charlson Comorbidity Indices and multi-way ANOVA. Amyloid status was not associated with verbal or visual delayed free recall memory indices or cognitive impairment. We found no association between amyloid status and HV in this group of ischemic stroke survivors.

Keywords: Amyloid imaging, atrophy, ¹⁸F-NAV4694, hippocampal volume, ischemic stroke, PET

DOI: 10.3233/JAD-201525

Journal: Journal of Alzheimer's Disease, vol. 80, no. 2, pp. 527-532, 2021