Affiliations: PsychoGenics, Inc., Paramus, NJ, USA
Correspondence:
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Correspondence to: Simon Gelman, 215 College Road, Paramus, NJ 07652, USA. Tel.: +1 201 746 8776; E-mail: simon.gelman@psychogenics.com.
Abstract: The timing of action potentials arrival at synaptic terminals partially determines integration of synaptic inputs and is important for information processing in the CNS. Therefore, axonal conduction velocity (VC) is a salient parameter, influencing the timing of synaptic inputs. Even small changes in VC may disrupt information coding in networks requiring accurate timing. We recorded compound action potentials in hippocampal slices to measure VC in three mouse models of Alzheimer’s disease. We report an age-dependent reduction in VC in area CA1 in two amyloid-β precursor protein transgenic mouse models, line 41 and APP/PS1, and in a tauopathy model, rTg4510.
