Affiliations: [a] Neurology, Neurophysiology and Neurobiology unit, Department of Medicine, University Campus Bio-Medico of Rome, Italy
| [b] Department of Neurosurgery, S. Maria Goretti Hospital, Latina, Italy
| [c]
Neurology, ASL di Aprilia, Italy
| [d] Edmond J. Safra Program in Parkinson’s Disease and the Morton and Gloria Shulman Movement Disorders Centre and the, Toronto Western Hospital, UHN, Toronto, Ontario, Canada
| [e] Division of Neurology, Department of Medicine, University of Toronto, Toronto, Canada
| [f]
Krembil Brain Institute, Toronto, Ontario, Canada
| [g]
CenteR for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, Canada
Correspondence:
[*]
Correspondence to: Dr. Massimo Marano, Neurology, Neurophysiology and Neurobiology unit; Department of Medicine, University Campus Bio-Medico of Rome, Viale Alvaro del Portillo 21, 00128, Rome, Italy. Tel.: +39 06225411220; Fax: +39 06225411936; E-mail: m.marano@unicampus.it, E-mail: masmarano@gmail.com.
Abstract: Down syndrome (DS) is the most common cause of intellectual disability in infants and has a well-known relationship with the Alzheimer’s disease. The association between DS and the other pathologies of senescence, such as normal pressure hydrocephalus (NPH), has been poorly investigated. This series included two DS patients with NPH. In both cases, NPH symptoms were initially misdiagnosed as DS associated senescence. Patients were treated with ventricular-peritoneal shunt, showing a sustained improvement (1 and 4 years of follow-up). To our knowledge, this is the first description of the occurrence of NPH in adult patients with DS and surgical outcomes.
Keywords: Cerebrospinal fluid, down syndrome, normal pressure hydrocephalus, trisomy 21, ventricular-peritoneal shunt
