Affiliations: [a] Shanghai University of Traditional Chinese Medicine, Shanghai, China
| [b] Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Lab of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, China
Correspondence:
[*]
Correspondence to: Dr. Jing-Shan Shi, Key Lab of Basic Pharmacology of Ministry of Education and Joint
International Research Lab of Ethnomedicine of Ministry of Education at Zunyi Medical University, Zunyi, China.
Tel.: +86 133 1443 8666; Fax: +86 852 860 9788; E-mails: shijingshan2018@163.com and shijs@zmu.edu.cn.
Abstract: Alzheimer’s disease (AD) is a highly age-related cognitive decline frequently attacking the elderly. Senescence-accelerated mouse-prone 8 (SAMP8) is an ideal model to study AD, displaying age-related learning and memory disorders. SAMP8 mice exhibit most features of pathogenesis of AD, including an abnormal expression of anti-aging factors, oxidative stress, inflammation, amyloid-β (Aβ) deposits, tau hyperphosphorylation, endoplasmic reticulum stress, abnormal autophagy activity, and disruption of intestinal flora. SAMP8 mice, therefore, have visualized the understanding of AD, and also provided effective ways to find new therapeutic targets. This review focused on the age-related pathogenesis in SAMP8 mice, to advance the understanding of age-related learning and memory decline and clarify the mechanisms. Furthermore, this review will provide extensive foundations for SAMP8 mice used in therapeutics for AD.
