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Article type: Short Communication
Authors: Wilson, George D.a; * | Wilson, Thomas G.a | Hanna, Alaaa | Fontanesi, Giovannia | Kulchycki, Justina | Buelow, Katiea | Pruetz, Barbara L.b | Michael, Daniel B.c; d | Chinnaiyan, Prakasha | Maddens, Michael E.e | Martinez, Alvaro A.f | Fontanesi, Jamesa; d
Affiliations: [a] Radiation Oncology Department, Beaumont Health, Royal Oak, MI, USA | [b] Beaumont Biobank, Beaumont Health, Royal Oak, MI, USA | [c] Michigan Head and Spine Institute, Southfield, MI, USA | [d] Department of Neurosurgery, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA | [e] Department of Internal Medicine, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA | [f] Radiation Oncology Institute, Division of Michigan Healthcare Professionals, Farmington Hills, MI, USA
Correspondence: [*] Correspondence to: George D. Wilson, PhD, William Beaumont Hospital, Department of Radiation Oncology, 3811W Thirteen Mile Road, Royal Oak, MI 48073, USA. E-mail: george.wilson@beaumont.edu.
Abstract: We have previously reported that low doses of external beam ionizing irradiation reduced amyloid-β (Aβ) plaques and improved cognition in APP/PS1 mice. In this study we investigated the effects of radiation in an age-matched series of 3xTg-AD mice. Mice were hemibrain-irradiated with 5 fractions of 2 Gy and sacrificed 8 weeks after the end of treatment. Aβ and tau were assessed using immunohistochemistry and quantified using image analysis with Definiens Tissue Studio. We observed a significant reduction in Aβ plaque burden and tau staining; these two parameters were significantly correlated. This preliminary data is further support that low doses of radiation may be beneficial in Alzheimer’s disease.
Keywords: Amyloid-β, radiation, reduction, tau
DOI: 10.3233/JAD-200030
Journal: Journal of Alzheimer's Disease, vol. 75, no. 1, pp. 15-21, 2020
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