Affiliations: [a] Edward Via Virginia College of Osteopathic Medicine, Blacksburg, VA, USA
| [b] Department of Radiology and Medical Imaging, University of Virginia School of Medicine, Charlottesville, VA, USA
| [c] Center for One Health Research, Virginia–Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA
Correspondence:
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Correspondence to: Blaise M. Costa, MPharm, PhD, Associate Professor of Pharmacology, Center for One Health Research, Virginia–Maryland College of Veterinary Medicine, 1410 Prices Fork Rd, Blacksburg, VA 24060, USA. Tel.: +1 540 231 1468; Fax: +1 540 231 3426; E-mail: bcosta@vcom.vt.edu.
Note: [1] Dr. Stuart Berr (sb4b@virginia.edu) should be contacted for questions on PET imaging.
Abstract: Current advancements in neurovascular biology relates a mechanoceutics treatment, known as cranial osteopathic manipulation (COM), Alzheimer’s disease (AD). COM could be used as an evidence-based treatment strategy to improve the symptoms of AD if molecular mechanisms, which currently remain unclear, are elucidated. In the present pilot study, using transgenic rats, we have identified COM mediated changes in behavioral and biochemical parameters associated with AD phenotypes. We expect these changes may have functional implications that might account for improved clinical outcomes of COM treatment. Further investigations on COM will be helpful to establish an adjunct treatment for AD.
