Affiliations: [a] Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Sakyo-ku Kyoto, Japan
| [b] Air Water Biodesign Inc., Kobe, Hyogo, Japan
| [c] Department of Medical Ethics and Medical Genetics, Kyoto University School of Public Health, Sakyo-ku Kyoto, Japan
| [d] Department of Health Informatics, Kyoto University School of Public Health, Sakyo-ku Kyoto, Japan
Correspondence:
[*]
Correspondence to: Yasuharu Tabara, Center for Genomic Medicine, Kyoto University Graduate School of
Medicine, Shogoinkawara-cho 53, Sakyo-ku, Kyoto 606-8507, Japan. Tel.: +81 75 751 4157; Fax: +81 75 751 4167;
E-mail: tabara@genome.med.kyoto-u.ac.jp.
Abstract: Accumulation of advanced glycation end products (AGEs) has been linked with cognitive decline as a risk factor based on the analysis in small populations. We investigated the association between skin autofluorescence of AGEs and global cognitive function in a Japanese older (≥60 years) population (n = 4,041). The AGEs quartiles were inversely associated with the Revised Hasegawa’s Dementia Scale score (Q1: reference, Q2: β= –0.011, p = 0.537, Q3: β= –0.043, p = 0.016, Q4: β= –0.064, p < 0.001) independent of major risk factors. Accumulation of AGEs was associated with lower cognitive performance in older adults.
Keywords: Advanced glycation end products, cognitive function, epidemiological
studies, population at risk
