Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Review Article
Authors: Shaughnessy, Keith A.a | Hackney, Kyle J.a | Clark, Brian C.b; c; d | Kraemer, William J.e | Terbizan, Donna J.a | Bailey, Ryan R.f | McGrath, Ryana; *
Affiliations: [a] Department of Health, Nutrition, and Exercise Sciences, North Dakota State University, Fargo, ND, USA | [b] Ohio Musculoskeletal and Neurological Institute, Ohio University, Athens, OH, USA | [c] Department of Biomedical Sciences, Ohio University, Athens, OH, USA | [d] Division of Geriatric Medicine, Ohio University, Athens, OH, USA | [e] Department of Human Sciences, The Ohio State University, Columbus, OH, USA | [f] Brown School of Social Work, Washington University in St. Louis, St. Louis, MO, USA
Correspondence: [*] Correspondence to: Ryan McGrath, Department of Health, Nutrition, and Exercise Sciences, North Dakota State University, NDSU Dept. 2620; PO Box 6050, Fargo, ND 58108, USA. Tel.: +1 701 231 7474; Fax: +1 701 231 8872; E-mail: ryan.mcgrath@ndsu.edu.
Abstract: Background:Measures of handgrip strength have not only emerged as a clinically viable screening tool for determining risk for morbidity, functional disability, and early mortality, but also for helping to identify cognitive deficits. However, the phenomena that links low handgrip strength with cognitive decline remains unclear. The role of the muscular and neural systems, and their adaptations to muscle strengthening activities over the life course, may provide important information for how age-related changes to muscle mass, strength, and neural capacity influence cognition. Moreover, disentangling how handgrip strength and cognitive function are associated may help to inform healthcare providers working with aging adults and guide targeted interventions aiming to preserve muscle and cognitive functioning. Objective:To 1) highlight and summarize evidence examining the associations of handgrip strength and cognitive functioning, and 2) provide directions for future research in this area. Methods:Articles from the PubMed database were searched from November 2018-May 2019. The search term algorithm, inclusion and exclusion criteria were pre-specified by investigators. Results:Several cross-sectional and longitudinal studies have revealed that measures of handgrip strength were associated with cognitive declines regardless of age demographics and the presence of comorbidities. Conclusion:Handgrip strength can be used in clinical and epidemiological settings for helping to determine the onset and progression of cognitive impairment. Future research should continue to examine how handgrip strength and cognitive function are linked.
Keywords: Aging, Alzheimer’s disease, cognition, dementia, muscle weakness, sarcopenia
DOI: 10.3233/JAD-190856
Journal: Journal of Alzheimer's Disease, vol. 73, no. 4, pp. 1265-1278, 2020
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl