Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Khandker, Rezaul K.a | Ritchie, Craig W.b | Black, Christopher M.a | Wood, Robertc | Jones, Eddiec; * | Hu, Xiaohand | Ambegaonkar, Baishali M.a
Affiliations: [a] Centre for Observational and Real-World Evidence, Merck & Co., Inc., Kenilworth, NJ, USA | [b] Centre for Dementia Prevention, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK | [c] Adelphi Real World, Bollington, Cheshire, UK | [d] University of Southern California, Los Angeles, CA, USA
Correspondence: [*] Correspondence to: Eddie Jones, Director, Adelphi Real World, Bollington, UK. Tel.: 0044 (0) 1625577336; E-mail: eddie.jones@adelphigroup.com.
Abstract: Background:Alzheimer’s disease (AD) is one of the most disabling conditions worldwide and the disease burden increases with the aging global population. There are only a few prospective studies using real-world data to support effective healthcare resource utilization (HCRU) in AD. Objective:To confirm the association between HCRU and AD severity in a real-world population, including patients with all cognitive impairment (CI) severities. Methods:Data were drawn from a multi-national, cross-sectional survey of physicians and their consulted patients with all stages (very mild, mild, moderate, and severe) of CI including AD conducted in France, Germany, Italy, Spain, UK, US, and Canada. Elements of HCRU including medical consultations, professional caregiver hours, hospitalization, and institutionalization were compared between CI severity subgroups, and by country and region. Results:6,143 CI patients were included with very mild (n = 659), mild (n = 2,473), moderate (n = 2,603), and severe (n = 408) dementia. HCRU increased with increasing CI severity (p < 0.001) for the majority of elements measured. Further analyses of overall and regional populations also confirmed significant increases in most HCRU elements with increasing disease severity. The general trend toward increased HCRU with increased CI severity was also seen in individual countries. Individual country data appeared to indicate that earlier intervention decreased hospitalizations and full-time institutionalization at the later (more severe) disease stages. Conclusion:Our findings confirmed that HCRU increases with increasing CI severity. Effective intervention in early disease could therefore reduce or delay incurring greater HCRU costs associated with more severe disease. Further studies are needed to confirm this hypothesis.
Keywords: Alzheimer’s disease, cognitive impairment, disease specific program, healthcare resource utilization
DOI: 10.3233/JAD-190760
Journal: Journal of Alzheimer's Disease, vol. 75, no. 4, pp. 1141-1152, 2020
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl