Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Review Article
Authors: Wang, Xiaonia; 1 | Sun, Yua; 1 | Li, Taorana | Cai, Yanningb | Han, Yinga; c; d; *
Affiliations: [a] Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China | [b] Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Beijing, China | [c] Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China | [d] National Clinical Research Center for Geriatric Disorders, Beijing, China
Correspondence: [*] Correspondence to: Ying Han, Department of Neurology, Xuanwu Hospital of Capital Medical University, Xicheng District, Beijing 100053, China. Tel.: +86 13621011941; E-mail: hanying@xwh.ccmu.edu.cn.
Note: [1] These authors contributed equally to this work.
Abstract: Alzheimer’s disease (AD), the main cause of dementia, is characterized by the aggregation of amyloid-β (Aβ). This pathophysiological process starts many years to decades before the onset of clinical symptoms. Cerebrospinal fluid analysis and amyloid positron emission tomography scans are two standard methods to measure brain Aβ, but their invasive nature and expense limit their usage as screening tools. Therefore, peripheral Aβ studies have grown exponentially during the past few years. In this review, we discuss recent studies on plasma Aβ and its potential as a reliable biomarker of AD.
Keywords: Alzheimer’s disease, biomarker, cognitive decline, plasma amyloid-beta
DOI: 10.3233/JAD-190714
Journal: Journal of Alzheimer's Disease, vol. 73, no. 3, pp. 819-832, 2020
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl