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Article type: Short Communication
Authors: Marcum, Zachary A.a; * | Hohl, Sarah D.b | Gray, Shelly L.a | Barthold, Douga | Crane, Paul K.c | Larson, Eric B.d
Affiliations: [a] University of Washington, School of Pharmacy, Seattle, WA, USA | [b] University of Washington, School of Public Health, Seattle, WA, USA | [c] University of Washington, School of Medicine, Seattle, WA, USA | [d] Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA
Correspondence: [*] Correspondence to: Zachary A. Marcum, PharmD, PhD, Department of Pharmacy, School of Pharmacy, University of Washington, 1959 NE Pacific St, Box 357630, Seattle, WA 98195, USA. Tel.: +1 206 685 2559; Fax: +1 206 543 3835; E-mail: zmarcum@uw.edu.
Abstract: We administered a mixed-method survey to 1,661 patients in a large health system to assess preferences toward antihypertensive use for dementia prevention. If a specific antihypertensive medication was shown to prevent or delay dementia, the vast majority (>90%) of respondents currently taking an antihypertensive reported that they would be willing to take that specific antihypertensive starting as early as mid-life. Concerns reported were potential side effects, lack of evidence of effectiveness, blood pressure being normal or low, and medication cost. Analysis of free-text responses revealed themes of concerns regarding evidence of effectiveness and health priorities.
Keywords: Alzheimer’s disease, antihypertensive agents, dementia, primary prevention
DOI: 10.3233/JAD-181080
Journal: Journal of Alzheimer's Disease, vol. 68, no. 2, pp. 523-529, 2019
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