Affiliations: [a] Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland
| [b] Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden
| [c] Department of Geriatrics, Karolinska University Hospital, Stockholm, Sweden
| [d] Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, UK
| [e] Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
Correspondence:
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Correspondence to: Jenni Kulmala, PhD, Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland. Tel.: +358 29 524 7142; E-mail: jenni.kulmala@thl.fi.
Abstract: During the last few years, dementia prevention based on modifiable lifestyle factors has gained increasing attention. Cohort studies with follow-ups extending up to decades have identified several risk and protective factors, and very recently new randomized controlled trials with multidomain approach have provided promising evidence by showing that modifying simultaneously several risk factors, it is possible to maintain and improve cognitive capacity among older at-risk persons. Several lifestyle-based multidomain trials are under preparation or ongoing and to facilitate international collaboration and effective worldwide dementia prevention, the World Wide FINGERS interdisciplinary network (http://wwfingers.com) was recently initiated. Additionally, several new implementation projects are taking the first steps from trial setting to real-life implementation of a dementia prevention program. This paper highlights the recent perspectives from the field of Alzheimer’s disease and reflects the implications and importance of current achievements. Finally, predictions for the future work especially in terms of global collaboration and implementation will be discussed.
