Exploring Potential Electrophysiological Biomarkers in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of Event-Related Potential Studies
Affiliations: Department of Neurology, Affiliated Zhong Da Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China
Correspondence:
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Correspondence to: Zhijun Zhang, Department of Neurology, Affiliated ZhongDa Hospital, Medical School, Southeast University, No. 87 Dingjiaqiao Road, Nanjing, Jiangsu, 210009, China. Tel.: +86 25 83262241; Fax: +86 25 83285132; E-mail: janemengzhang@vip.163.com.
Abstract: Background: Early diagnosis and effective management are pivotal steps in preventing the transition from mild cognitive impairment (MCI) to Alzheimer’s disease. Previous investigations indicated that some event-related potential (ERP) components in MCI are sensitive to cognitive decline. However, several comparative analyses of these components in MCI and healthy controls (HC) yielded inconsistent results. Objective: The aim was to perform a systematic review and meta-analysis of ERP studies on MCI patients. Methods: We systematically searched on PubMed and Web of Science for MCI-related ERP studies published from April 1986 to August 2016. Standard mean difference estimates of all components were compared between MCI and HC. Results: Our study showed increased P50 amplitude at the Cz site; reduced N2pc amplitude and delayed P200 latency at the Cz site; N200 latency at the Cz and Pz sites, and P300 latency at the Cz and Pz sites in MCI patients compared to HC. Conclusions: In summary, our study indicated that some ERP components, such as P50 and N2pc amplitude, P200, N200, and P300 latency might be potential electrophysiological biomarkers for MCI diagnosis.
