Affiliations: [a] Department of Radiology, Clínica Universidad de Navarra, Pamplona, Spain
| [b] Department of Biomedical Engineering, TECNUN Engineering School, University of Navarra, San Sebastián, Spain
| [c] Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
| [d] Department of Neurology, Clínica Universidad de Navarra, Pamplona, Spain
Correspondence:
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Correspondence to: María A. Fernández-Seara, Department of Radiology, Clínica Universidad de Navarra, Pio XII, 36, 31008, Pamplona, Spain. Tel.: +34 948 255400; E-mail: mfseara@unav.es.
Abstract: There is increasing evidence of a vascular contribution to Alzheimer’s disease (AD). In some cases, prior work suggests that chronic brain hypoperfusion could play a prime pathogenic role contributing to the accumulation of amyloid-β,while other studies favor the hypothesis that vascular dysfunction and amyloid pathology are independent, although synergistic, mechanisms contributing to cognitive impairment. Vascular dysfunction can be evaluated by assessing cerebral blood flow impairment. Phase contrast velocity mapping by MRI offers a non-invasive means of quantifying the total inflow of blood to the brain. This quantitative parameter could be a sensitive indicator of vascular disease at early stages of AD. In this work, phase contrast MRI was used to evaluate cerebral hemodynamics in patients with subjective memory complaints, amnestic mild cognitive impairment, and mild to moderate AD, and compare them with control subjects. Results showed that blood flow and velocity were decreased in the patients with cognitive dysfunction and the decrease correlated with the degree of cognitive impairment as assessed by means of neuropsychological tests. Total cerebral blood flow measurements were clearly reduced in AD patients, but more importantly appeared to be sensitive enough to distinguish between healthy subjects and those with mild cognitive impairment. A quantitative measurement of total brain blood flow could potentially predict vascular dysfunction and compromised brain perfusion in early stages of AD.
